Understanding Wagyu Genetic Conditions
Our Commitment to Responsible Breeding at 22 Wagyu
At 22 Wagyu, genetic integrity is one of the most important foundations of our breeding program. Fullblood Wagyu cattle are globally recognized for exceptional marbling, maternal strength, and carcass quality — and protecting those genetics requires transparency, education, and responsible selection.
Modern DNA testing allows Wagyu breeders to identify certain recessive genetic conditions that may exist within bloodlines outside of Japan. These conditions are well understood today and can be effectively managed through informed breeding decisions.
What Are Recessive Genetic Conditions?
A recessive genetic condition occurs only when a calf inherits one copy of a gene from both parents.
Free × Free → No risk
Carrier × Free → Healthy calf (may be a carrier)
Carrier × Carrier → 25% chance of an affected calf
Importantly, carrier animals are often elite cattle with outstanding performance genetics. Responsible breeders manage risk through proper mating selection rather than eliminating valuable bloodlines.
At 22 Wagyu, all breeding decisions are made with genetic compatibility in mind.
Known Wagyu Recessive Conditions
B3 — Band 3 Deficiency
Band 3 Deficiency affects red blood cell function and can result in severe anemia in affected calves. Animals expressing this condition typically show weakness early in life and may not survive. DNA testing allows breeders to prevent affected matings entirely.
CHS — Chediak-Higashi Syndrome
This condition impacts immune function and blood clotting ability. Affected animals may experience increased susceptibility to illness and reduced survivability. Careful genetic screening prevents occurrence within managed breeding programs.
CL16 — Claudin-16 Deficiency
CL16 affects kidney function and mineral regulation. While animals may appear normal early in life, long-term productivity can be compromised. Responsible mating strategies eliminate the risk of affected offspring.
F11 — Factor XI Deficiency
Factor XI Deficiency is a blood clotting disorder that may lead to prolonged bleeding or reduced reproductive efficiency. This condition is widely tested for across modern Wagyu programs.
IARS — Isoleucyl-tRNA Synthetase Deficiency
IARS can result in weak calf syndrome, poor growth performance, and reduced immune response. Advances in genomic testing allow breeders to identify carriers and make safe breeding decisions.
Others Identified Through Ongoing Research
As genetic science advances, additional markers continue to be studied within global Wagyu populations. Continuous testing and transparency remain essential to maintaining herd quality for future generations.
The 22 Wagyu Standard
Our philosophy is simple:
✅ DNA-informed breeding decisions
✅ Transparency with buyers and partners
✅ Preservation of elite Wagyu bloodlines
✅ Long-term herd health and performance
All breeding cattle within the 22 Wagyu program are evaluated using modern genetic testing to ensure responsible pairings and predictable outcomes.
We believe great Wagyu programs are built not only on exceptional carcass genetics — but on sound science, stewardship, and trust.
Why This Matters to Our Customers
Whether purchasing breeding stock or premium Wagyu beef, responsible genetic management ensures:
Healthier cattle
Strong maternal performance
Consistent carcass quality
Long-term genetic sustainability
Our goal is to provide cattle and beef backed by confidence, data, and integrity.
22 Wagyu
Know Your Wagyu.